NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

Which drug requires administration with a meal and water for effective absorption?

1. Efavirenz

2. Rilpivirene

3. Dolutegravir

4. Atazanavir

The correct answer is: Rilpivirene

B Rilpivirine is the correct answer because it is a non-nucleoside reverse transcriptase inhibitor that requires a meal and plenty of water for optimal absorption in the body. It is important to take this medication with a meal as it can decrease its absorption, and with water to ensure proper distribution in the body. A: Efavirenz is a non-nucleoside reverse transcriptase inhibitor like Rilpivirine, but it does not require administration with a meal or water for effective absorption. In fact, taking Efavirenz on an empty stomach can increase its absorption and effectiveness. C: Dolutegravir is an integrase inhibitor that does not require administration with a meal or water for effective absorption. It is generally well-tolerated and can be taken with or without food. D: Atazanavir is a protease inhibitor that is better absorbed when taken with a meal. However, it does not require administration with water like Rilpivirine. Therefore, Rilpivirine is the best answer as it specifically requires a meal and water for optimal absorption, while the other options may have varying absorption requirements.