NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which generation of cephalosporins includes drugs with broad gram-negative activity including HNPEK, CAPES, and Pseudomonas?

  1. 1st generation

  2. 2nd generation

  3. 3rd generation

  4. 4th generation

The correct answer is: 4th generation

The fourth generation of cephalosporins is considered to have the broadest spectrum of activity against gram-negative bacteria, including organisms such as HNPEK, CAPES, and Pseudomonas. The first generation is primarily effective against gram-positive bacteria, while the second and third generations have increasing levels of gram-negative activity, but not to the extent of the fourth generation. Therefore, options A, B, and C are incorrect.

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