NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which group of drugs can induce drug-induced Raynaud's phenomenon besides beta-blockers?

  1. Contraceptives with less than 35mcg Estrogen

  2. Aminoglycosides and quinolones

  3. Bleomycin, cisplatin, sympathomimetics

  4. Monophasic COCs

The correct answer is: Bleomycin, cisplatin, sympathomimetics

While estrogen-containing oral contraceptives may induce Raynaud's phenomenon with a concentration of less than 35mcg, they are not the only group of drugs that can do so. Aminoglycosides and quinolones may also cause drug-induced Raynaud's phenomenon due to their effects on blood vessels and circulation. But the group of drugs that is most known to induce this phenomenon are bleomycin, cisplatin, and sympathomimetics. Monophasic COCs refer to a type of oral contraceptive pill with the same dosage of estrogen and progesterone in each pill, and these are not commonly associated with inducing Raynaud's phenomenon.

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