NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which group of drugs is known to increase both LDL and TG?

  1. NRTIs

  2. Protease Inhibitors

  3. NNRTIs

  4. INSTIs

The correct answer is: Protease Inhibitors

Protease Inhibitors are known to increase both LDL (low-density lipoprotein) and TG (triglycerides) levels. These drugs can lead to dyslipidemia, which is characterized by elevated levels of LDL and triglycerides in the blood. This is an important consideration when prescribing protease inhibitors to patients, especially those who may already have underlying cardiovascular risk factors. The other options, such as NRTIs (nucleoside reverse transcriptase inhibitors), NNRTIs (non-nucleoside reverse transcriptase inhibitors), and INSTIs (integrase strand transfer inhibitors), are not typically associated with increasing both LDL and triglyceride levels. Therefore, Protease Inhibitors are the correct answer in this case.

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