NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

Which immunosuppressant drug requires premedication to lessen infusion reactions?

1. Everolimus

2. Basiliximab

3. Tacrolimus

4. Antithymocyte globulin

The correct answer is: Antithymocyte globulin

Antithymocyte globulin is the correct answer because it is a potent immunosuppressant drug that requires premedication with antihistamines, corticosteroids, and acetaminophen to reduce the likelihood and severity of infusion reactions such as fever, chills, and rash. This is because antithymocyte globulin works by targeting and destroying T cells, which are a crucial part of the immune response. As for the other options - Everolimus is an immunosuppressant drug that works by inhibiting a protein involved in cell growth and proliferation. While it does have some side effects, such as decreased white blood cell count, it does not typically require premedication. - Basiliximab is a monoclonal antibody that also suppresses immune responses by targeting specific proteins. It is generally well-tolerated and does not require premedication. - Tacrolimus is an immunosuppressant drug commonly used in organ transplant patients. While it can have side effects such as tremors and high blood pressure, it does not typically require premedication. Overall, antithymocyte globulin is the only option that specifically requires premedication due to its potent immunos