NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which is a treatment option for low emetic risk CINV?

  1. NK1-RA

  2. 5HT3-RA

  3. Corticosteroids

  4. Benzos

The correct answer is: 5HT3-RA

For low emetic risk chemotherapy-induced nausea and vomiting (CINV), the appropriate treatment option is a 5HT3 receptor antagonist (5HT3-RA). 5HT3 receptor antagonists are effective in preventing and treating acute nausea and vomiting associated with chemotherapy. They work by blocking serotonin in the gut and centrally. Options A, C, and D are not typically recommended as first-line treatments for low emetic risk CINV. NK1 receptor antagonists (NK1-RAs) are usually reserved for high emetic risk CINV, corticosteroids may be used in combination with other antiemetics for moderate to high emetic risk CINV, and benzos are not commonly used for CINV treatment.

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