NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which medication combination is NOT recommended for moderate emetic risk?

  1. NK1-RA + 5HT3-RA + Dexamethasone

  2. 5HT3-RA + Dexamethasone

  3. 5HT3-RA + Corticosteroids

  4. Palonosetron + Olanzapine + Dexamethasone

The correct answer is: 5HT3-RA + Corticosteroids

The medication combination that is NOT recommended for moderate emetic risk is 5HT3-RA + Corticosteroids (Choice C). This is because for moderate emetic risk, the preferred regimen typically involves using a 5HT3 receptor antagonist in combination with a neurokinin-1 receptor antagonist (NK1-RA) and dexamethasone (Choice A). This triple combination provides a comprehensive antiemetic effect. While 5HT3-RA + corticosteroids (Choice C) may be effective in preventing nausea and vomiting, it is not the preferred combination for moderate emetic risk when compared to the triple therapy of NK1-RA + 5HT3-RA + dexamethasone (Choice A). The other options can be ruled out as they are not the standard therapy for moderate emetic risk.

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