NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which medication combination is not recommended for treating HAP/VAP due to the risk of resistance?

  1. Cefepime and Gentamicin

  2. Pip/Tazo and Cipro

  3. Two beta-lactams

  4. Vancomycin and Linezolid

The correct answer is: Two beta-lactams

The combination of two beta-lactam antibiotics is not recommended for treating Hospital-Acquired Pneumonia (HAP) or Ventilator-Associated Pneumonia (VAP) due to the risk of resistance. Using two beta-lactam antibiotics together may not provide additional benefit and can increase the risk of developing antimicrobial resistance. It is important to limit the use of antibiotics to avoid resistance and ensure effective treatment for patients with HAP/VAP. Choices A, B, and D involve different classes of antibiotics that are commonly used in the treatment of HAP/VAP and are generally considered appropriate choices depending on the specific microbial etiology and patient factors.

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