NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which medication does not require adjustment for creatinine clearance (CrCl) according to the text?

  1. Descovy

  2. Truvada

  3. Both Descovy and Truvada

  4. Neither Descovy nor Truvada

The correct answer is: Neither Descovy nor Truvada

Both Descovy and Truvada are medications used for pre-exposure prophylaxis (PrEP) against HIV. Descovy contains a newer form of tenofovir that has been shown to be less harmful to the kidneys compared to the older form of tenofovir found in Truvada. This difference allows Descovy to be used without requiring adjustment for creatinine clearance (CrCl), making option D the correct answer.

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