NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

Disable ads (and more) with a membership for a one time $4.99 payment

Ace your North American Pharmacist Licensure Examination (NAPLEX) with our comprehensive practice test. Features include interactive flashcards, multiple-choice questions, with detailed hints and explanations. Fast-track your pharmacy career today!

Start Multiple Choice Practice Test
Start Flash Cards

Practice this question and more.

Which medication has the highest COX-2 selectivity?

  1. Celecoxib (Celebrex)

  2. Diclofenac (Voltaren)

  3. Meloxicam (Mobic)

  4. Ibuprofen (Advil)

The correct answer is: Celecoxib (Celebrex)

Celecoxib (Celebrex) has the highest COX-2 selectivity among the options provided. COX-2 inhibitors like celecoxib selectively inhibit the cyclooxygenase-2 enzyme, which is responsible for inflammation and pain, while sparing the cyclooxygenase-1 (COX-1) enzyme that helps maintain the stomach lining and normal platelet function. This selectivity helps reduce the risk of gastrointestinal ulcers and bleeding compared to non-selective NSAIDs like diclofenac, meloxicam, and ibuprofen. Thus, celecoxib is preferred in patients who are at higher risk of gastrointestinal complications.

More Questions Like This