NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

Disable ads (and more) with a membership for a one time $4.99 payment

Ace your North American Pharmacist Licensure Examination (NAPLEX) with our comprehensive practice test. Features include interactive flashcards, multiple-choice questions, with detailed hints and explanations. Fast-track your pharmacy career today!

Practice this question and more.

Which medication is a CYP-2D6 substrate?

Paroxetine
Methadone
Amiodarone
Esomeprazole

The correct answer is: Methadone

Methadone is the correct answer because it is known to be a substrate of the CYP-2D6 enzyme. Paroxetine, Amiodarone, and Esomeprazole are not known to be substrates of this specific enzyme. Paroxetine is metabolized by CYP-2C19, Amiodarone by CYP-3A4, and Esomeprazole by CYP-2C19 and CYP-3A4. While some medications may be metabolized by multiple enzymes, only Methadone is widely recognized and studied as a CYP-2D6 substrate.