NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which medication is a SAMA for COPD treatment?

  1. Tiotropium

  2. Ipratropium bromide + albuterol

  3. Rolumilast

  4. Salmeterol

The correct answer is: Ipratropium bromide + albuterol

SAMA (Short-acting muscarinic antagonist) medications are used to treat COPD (Chronic obstructive pulmonary disease). Tiotropium, although a muscarinic antagonist, is classified as a LAMA (long-acting muscarinic antagonist), and is not a SAMA as the question specifies. Rolumilast is a phosphodiesterase-4 (PDE4) inhibitor, and while it may be used as a treatment for COPD, it is not a SAMA medication. Salmeterol is a long-acting bronchodilator but is not a muscarinic antagonist, so it is also not a SAMA medication. The correct choice, B, is a combination medication of Ipratropium bromide and albuterol, both of which are SAMA medications used to treat COPD.

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