NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which medication is indicated for opioid-induced constipation (OIC) only after failing OTC laxatives?

  1. Lubiprostone

  2. Methylnaltrexone

  3. Senna

  4. Bisacodyl

The correct answer is: Methylnaltrexone

Methylnaltrexone is the only medication specifically indicated for opioid-induced constipation (OIC) after failing OTC laxatives. Lubiprostone is indicated for chronic idiopathic constipation and irritable bowel syndrome with constipation. Senna and bisacodyl are both laxatives that can be used for general constipation but are not specifically indicated for OIC. Additionally, bisacodyl should not be taken for more than 7 days without consulting a doctor. While all the options may provide relief from constipation, methylnaltrexone would be the best choice for OIC in this scenario.

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