NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which medication is not associated with Hand-foot syndrome (PPE)?

  1. Capecitabine

  2. Cytarabine

  3. Dexamethasone

  4. Sunitinib

The correct answer is: Dexamethasone

Hand-foot syndrome (Palmar-Plantar Erythrodysesthesia or PPE) is a known side effect of certain chemotherapy medications. Capecitabine, cytarabine, and sunitinib are all associated with the development of Hand-foot syndrome. However, dexamethasone is not known to cause this particular adverse reaction. Dexamethasone is a corticosteroid medication commonly used to reduce inflammation and suppress the immune system in a variety of conditions, but it is not typically linked to Hand-foot syndrome.

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