NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

Which medication is used as an adjunctive treatment with Cisplatin to manage side effects?

1. Amifostine and hydration

2. Dexrazoxane

3. Leucovorin

4. Mesna + hydration

The correct answer is: Amifostine and hydration

Cisplatin is a chemotherapy drug commonly used in the treatment of various types of cancer. However, it can cause severe side effects such as kidney damage, nausea, vomiting, and neuropathy. An adjunctive treatment is a secondary medication used in combination with the primary treatment to help manage side effects and enhance the effectiveness of the primary treatment. Out of the options given, Amifostine is the best adjunctive treatment for reducing the side effects of Cisplatin. Leucovorin, also known as folinic acid, is a medication used to reduce the toxicity of methotrexate (another chemotherapy drug) and help it work more effectively. It is not commonly used as an adjunctive treatment with Cisplatin. Dexrazoxane is another chemotherapy drug used to treat specific types of cancer, such as breast cancer. It is not typically used as an adjunctive treatment with Cisplatin. Mesna is a medication used to protect the bladder from the harmful effects of a chemotherapy drug called Ifosfamide. It is not used as an adjunctive treatment with Cisplatin and does not help manage its side effects. However, hydration, which is often used in combination with