NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which medication should be avoided in G6PD deficiency when treating acne?

Clindamycin
Salicylic Acid
Dapsone Gel
Azelaic Acid

The correct answer is: Dapsone Gel

G6PD deficiency is an inherited condition where a person lacks an enzyme which helps to protect red blood cells. This enzyme deficiency can lead to red blood cell damage when exposed to certain medications, infections, or other triggers. Dapsone Gel is the most suitable treatment option for acne patients with G6PD deficiency as it is not associated with the hemolytic anemia that can occur in these individuals. Clindamycin and Azelaic Acid are not recommended for use in patients with this condition due to their potential to trigger hemolytic reactions. Salicylic acid should be avoided as it can cause acute hemolytic anemia in people with G6PD deficiency.