NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

Disable ads (and more) with a membership for a one time $4.99 payment

Ace your North American Pharmacist Licensure Examination (NAPLEX) with our comprehensive practice test. Features include interactive flashcards, multiple-choice questions, with detailed hints and explanations. Fast-track your pharmacy career today!

Practice this question and more.

Which of the following are CYP3A4 substrates?

Hydrocodone, fentanyl, methadone, oxycodone
Aspirin, ibuprofen, naproxen
Acetaminophen, tramadol, celecoxib
Lorazepam, alprazolam, diazepam

The correct answer is: Hydrocodone, fentanyl, methadone, oxycodone

CYP3A4 is a type of enzyme found in the liver that is responsible for metabolizing many substances, including medications. It is known for its role in the metabolism of opioids, such as hydrocodone, fentanyl, methadone, and oxycodone. Therefore, the correct answer is A. The other options (B, C, and D) are incorrect because they do not include opioids, which are the primary substrates for CYP3A4. Aspirin, ibuprofen, and naproxen (option B) are non-steroidal anti-inflammatory drugs (NSAIDs) that are typically metabolized by other enzymes in the liver. Acetaminophen, tramadol, and celecoxib (option C) are also not substrates for CYP3A4. Finally, lorazepam, alprazolam, and diazepam (option D) are benzodiazepines, which are metabolized by different enzymes in the liver. Therefore, they are not considered CYP3A4 substrates.