NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which of the following Azole antifungals penetrates the CNS?

  1. Fluconazole

  2. Itraconazole

  3. Voriconazole

  4. Ketoconazole

The correct answer is: Fluconazole

Fluconazole is the correct answer because it is the only Azole antifungal in the list that penetrates the central nervous system (CNS) effectively. Fluconazole has excellent penetration into the cerebrospinal fluid, making it a preferred choice for treating fungal infections in the CNS such as cryptococcal meningitis. The other options, Itraconazole, Voriconazole, and Ketoconazole, have minimal penetration into the CNS compared to Fluconazole and are not typically used for CNS fungal infections.

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