NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which of the following classes of drugs is NOT recommended in heart failure due to worsening of the condition?

  1. Dipeptidyl peptidase 4 inhibitors

  2. Beta-blockers

  3. Aldosterone receptor antagonists

  4. Non-DHP CCBs

The correct answer is: Non-DHP CCBs

Non-DHP CCBs are not recommended in heart failure due to their negative inotropic effects which can worsen the condition. This class of drugs can lead to decreased cardiac contractility and worsen heart failure symptoms. On the other hand, dipeptidyl peptidase 4 inhibitors, beta-blockers, and aldosterone receptor antagonists are commonly used and recommended in heart failure management to improve symptoms and outcomes.

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