NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which of the following drugs can cause drug-induced lupus erythematous (DILE)?

  1. Methimazole

  2. Lisinopril

  3. Acetaminophen

  4. Amlodipine

The correct answer is: Methimazole

Drug-induced lupus erythematous (DILE) is a rare adverse effect caused by certain medications. Methimazole, a medication used to treat hyperthyroidism, is known to be associated with the development of DILE. While all the other options (Lisinopril, Acetaminophen, and Amlodipine) are commonly prescribed medications, they are not typically associated with causing DILE. DILE typically presents with symptoms similar to systemic lupus erythematosus (SLE), such as arthralgia, myalgia, fever, and rash, and it usually resolves after discontinuation of the offending medication.

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