NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which of the following drugs is a cause of agranulocytosis?

  1. Clozapine

  2. Acetaminophen

  3. Lisinopril

  4. Atorvastatin

The correct answer is: Clozapine

Agranulocytosis is a potentially life-threatening condition characterized by a severe decrease in circulating granulocytes, specifically neutrophils. Clozapine, an atypical antipsychotic medication, is known to be associated with the development of agranulocytosis. Regular monitoring of white blood cell counts, specifically absolute neutrophil count (ANC), is recommended for patients taking clozapine due to the risk of agranulocytosis. Acetaminophen, lisinopril, and atorvastatin are not known to be causes of agranulocytosis.