NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which of the following is NOT an effect of TKIs?

Diarrhea
Hepatotoxicity
Constipation
QT prolongation

The correct answer is: Constipation

TKIs, or tyrosine kinase inhibitors, are a type of targeted therapy commonly used in cancer treatment. They work by blocking the activity of specific proteins, known as tyrosine kinases, that contribute to the growth and spread of cancer cells. Option A, diarrhea, is a common side effect of TKIs due to their effect on the gastrointestinal system. Option B, hepatotoxicity, refers to liver damage or injury caused by substances such as medications. TKIs are known to have potential for hepatotoxicity, with symptoms ranging from mild elevation of liver enzymes to severe liver failure. Option D, QT prolongation, is a potential complication of TKIs where the heart's QT interval, which represents the time it takes for the heart to recharge between beats, is longer than normal. This can cause disruption in the heart's electrical activity and lead to dangerous heart rhythms. Therefore, option C, constipation, is incorrect as TKIs do not have any known effects on constipation.