NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which of the following is NOT a common adverse effect of alkylating agents?

Myelosuppression
Moderate-high emetic potential
Increased glucose levels
Secondary malignancies

The correct answer is: Increased glucose levels

Alkylating agents are a class of chemotherapy drugs that work by attaching an alkyl group to DNA, leading to cell death. Common adverse effects of alkylating agents include myelosuppression (bone marrow suppression leading to low blood cell counts), moderate to high emetic potential (nausea and vomiting), and an increased risk of developing secondary malignancies due to their potential to damage normal cells in addition to cancer cells. Increased glucose levels (hyperglycemia) are not commonly associated with alkylating agents. This side effect is more commonly seen with medications like corticosteroids or certain targeted therapies.