NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which of the following is a characteristic side effect of Vinca alkaloids?

  1. Hand-foot syndrome

  2. Peripheral neuropathy

  3. Infusion-related hypersensitivity

  4. QT prolongation

The correct answer is: Peripheral neuropathy

Vinca alkaloids, such as vincristine and vinblastine, are known to cause peripheral neuropathy as a characteristic side effect. Peripheral neuropathy is a common adverse effect of Vinca alkaloids due to their neurotoxic effects on peripheral nerves. Symptoms of peripheral neuropathy include numbness, tingling, and burning sensations in the hands and feet. Hand-foot syndrome, infusion-related hypersensitivity, and QT prolongation are not typically associated with Vinca alkaloids.

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