NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Ace your North American Pharmacist Licensure Examination (NAPLEX) with our comprehensive practice test. Features include interactive flashcards, multiple-choice questions, with detailed hints and explanations. Fast-track your pharmacy career today!

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Which of the following is not a CYP-3A4 substrate?

Lovastatin
Amiodarone
Clarithromycin
Tadalafil

The correct answer is: Clarithromycin

C Clarithromycin is not a CYP-3A4 substrate. This is because it is actually a CYP-3A4 inhibitor, meaning it blocks the enzyme's activity. This can lead to an increase in the levels of other drugs metabolized by CYP-3A4, potentially causing adverse effects. A: Lovastatin, B: Amiodarone, and D: Tadalafil are all CYP-3A4 substrates. This means that they are metabolized by the enzyme and can be affected by other drugs that either inhibit or induce CYP-3A4 activity. Therefore, it is important for patients taking these medications to be aware of potential drug interactions.