NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which of the following is a CYP-2C19 substrate?

  1. clopidogrel

  2. fluoxetine

  3. amiodarone

  4. fluoxetine

The correct answer is: clopidogrel

Clopidogrel is the correct answer as it is a known substrate of the CYP-2C19 enzyme. The CYP-2C19 enzyme is responsible for metabolizing a variety of drugs, including clopidogrel. When clopidogrel is administered, it undergoes activation in the liver with the help of CYP-2C19 to its active form, which plays a crucial role in its antiplatelet effects. Amiodarone is primarily metabolized by the CYP-3A4 enzyme, and fluoxetine is mainly metabolized by CYP-2D6. Therefore, these drugs are not substrates of CYP-2C19.

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