NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Ace your North American Pharmacist Licensure Examination (NAPLEX) with our comprehensive practice test. Features include interactive flashcards, multiple-choice questions, with detailed hints and explanations. Fast-track your pharmacy career today!

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Which of the following is a CYP-3A4 substrate?

Fentanyl
Ciprofloxacin
Carbamazepine
Amiodarone

The correct answer is: Fentanyl

CYP-3A4 is an enzyme found in the liver that plays a crucial role in breaking down various medications, known as substrates. The question is asking for a specific substrate that is processed by this enzyme. Option A, Fentanyl, is the correct answer as it is a potent pain medication that is metabolized by CYP-3A4. The other options, B, C, and D, are not substrates for CYP-3A4. Ciprofloxacin (B) is an antibiotic that is metabolized by other enzymes. Carbamazepine (C) is an anticonvulsant that is also metabolized by other enzymes. Amiodarone (D) is an antiarrhythmic medication that is metabolized by both CYP-3A4 and other enzymes. Therefore, while amiodarone is a substrate for CYP-3A4, it is not the only answer and should not be selected.