NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which of the following is NOT a Black Box Warning for Quinolones?

  1. Nephrotoxicity

  2. Tendon inflammation/rupture

  3. Peripheral neuropathy

  4. CNS effects

The correct answer is: Nephrotoxicity

Quinolones are a class of antibiotics known to have several potential serious side effects, some of which carry Black Box Warnings. A Black Box Warning is the strictest warning put in the labeling of prescription drugs by the FDA when there is reasonable evidence of an association of a serious hazard with the drug. Nephrotoxicity is not typically associated with quinolones, which is why it is NOT a Black Box Warning for this class of antibiotics. Tendon inflammation/rupture, peripheral neuropathy, and CNS effects are all known Black Box Warnings for quinolones due to the potential serious risks they pose to patients taking these medications.

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