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Which of the following is a non-DHP CCB?
Amlodipine
Nifedipine
Verapamil
Clevidipine
The correct answer is: Verapamil
Verapamil is the correct answer as it is a non-DHP (dihydropyridine) calcium channel blocker (CCB). Verapamil belongs to the non-DHP CCB class, which works by inhibiting calcium ion influx through L-type calcium channels in the heart and smooth muscle cells. This action results in vasodilation and decreased heart rate, making verapamil suitable for conditions like hypertension, angina, and certain arrhythmias. Amlodipine and Nifedipine are examples of DHP CCBs, which primarily act on vascular smooth muscle and are commonly used to treat hypertension and angina. Clevidipine, on the other hand, is a newer intravenous medication used for the rapid reduction of blood pressure in perioperative and acute hypertensive situations.