NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which of the following is not a noted side effect of macrolides?

  1. QT prolongation

  2. Hepatotoxicity

  3. Photosensitivity

  4. Increased K+

The correct answer is: Increased K+

Macrolides are antibiotics often prescribed to treat respiratory tract infections. Reports of QT prolongation and hepatotoxicity are common, but increased levels of potassium (hyperkalemia) is not a commonly noted side effect. Other known side effects of macrolides include nausea, vomiting, diarrhea, and abdominal pain. Therefore, increased K+ is the only option that is not a noted side effect of macrolides.

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