NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which of the following is NOT an effect of dopamine depending on the dose?

  1. DA-1 agonist

  2. B-1 agonist

  3. A-2 agonist

  4. A-1 agonist

The correct answer is: A-2 agonist

Dopamine has different effects on the body depending on the dose and its interaction with various receptors. At low doses, dopamine primarily acts on DA-1 receptors, leading to vasodilation in the renal, mesenteric, and coronary beds. This effect is known as a DA-1 agonist effect. At moderate doses, dopamine stimulates B-1 receptors, resulting in increased heart rate and contractility. This is the B-1 agonist effect of dopamine. At high doses, dopamine can stimulate A-1 receptors, causing vasoconstriction in the systemic vasculature. The A-2 agonist effect is not one of the typical effects of dopamine based on dose and receptor interaction.

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