NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which of the following is a first-line medication for diabetes in CKD patients?

  1. Insulin

  2. SGLT2 inhibitors

  3. Sulfonylureas

  4. Thiazolidinediones

The correct answer is: SGLT2 inhibitors

In chronic kidney disease (CKD) patients, SGLT2 inhibitors are considered a first-line medication for diabetes management. SGLT2 inhibitors have shown benefits in reducing cardiovascular events and progression of kidney disease in patients with CKD. Additionally, they do not require dose adjustments based on renal function, making them a favorable choice in this patient population. Insulin, sulfonylureas, and thiazolidinediones may not be preferred as first-line options in CKD patients due to various factors such as risk of hypoglycemia, weight gain, and potential adverse effects on kidney function.

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