NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which of the following is not a side effect of bisphosphonates?

Dyspepsia
Leg cramps
Heartburn
Hypocalcemia

The correct answer is: Leg cramps

Bisphosphonates are commonly used to treat osteoporosis by inhibiting bone resorption. Side effects of bisphosphonates include gastrointestinal symptoms like dyspepsia (A) and heartburn (C) due to irritation of the esophagus. Hypocalcemia (D) is also a potential side effect of bisphosphonate therapy as these medications can interfere with calcium metabolism. Leg cramps (option B) are not typically associated with bisphosphonate use and are not considered a side effect of this class of drugs.