NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which of the following is a characteristic of NNRTIs?

  1. Low barrier to resistance

  2. Associated with weight gain

  3. Hepatotoxicity and rash

  4. Recommended for initial treatment in all patients

The correct answer is: Hepatotoxicity and rash

NNRTIs (Non-Nucleoside Reverse Transcriptase Inhibitors) are a class of antiretroviral drugs commonly used to treat HIV infection. One of the characteristic adverse effects associated with NNRTIs is hepatotoxicity and rash. These drugs can cause liver toxicity, ranging from asymptomatic elevation of liver enzymes to severe hepatotoxicity. Additionally, NNRTIs are known to cause various types of skin reactions, including rash. Therefore, option C is the correct choice as it accurately describes a characteristic commonly associated with NNRTIs. Options A, B, and D are not characteristics of NNRTIs. NNRTIs actually have a relatively high barrier to resistance compared to other antiretroviral classes. Weight gain is not commonly associated with NNRTIs. Finally, NNRTIs are not recommended for initial treatment in all patients; the choice of HIV regimen is based on various factors including patient's comorbidities, concomitant medications, drug-drug interactions, and previous treatment history.

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