NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which of the following pathogens is commonly resistant?

  1. E. coli (ESBL, CRI)

  2. Haemophilus influenzae

  3. Neisseria meningitidis

  4. Streptococcus pneumoniae

The correct answer is: E. coli (ESBL, CRI)

E. coli is commonly associated with resistance, specifically due to two mechanisms - ESBL (extended-spectrum beta-lactamase) production and CRI (carbapenem-resistant Enterobacteriaceae). ESBL-producing E. coli strains are resistant to most beta-lactam antibiotics, making treatment challenging. Similarly, CRI in E. coli leads to resistance against carbapenem antibiotics, which are often considered as a last-line treatment for multidrug-resistant infections. Therefore, in the context of antimicrobial resistance, E. coli is a notable pathogen to consider for its resistance patterns, making it the correct answer in this scenario. Haemophilus influenzae, Neisseria meningitidis, and Streptococcus pneumoniae are all pathogens of clinical significance, but they are generally less commonly associated with resistance compared to E. coli.

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