NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which potassium-sparing diuretic is a selective aldosterone antagonist without endocrine side effects?

  1. Spironolactone

  2. Amiloride

  3. Eplerenone

  4. Triamterene

The correct answer is: Eplerenone

Eplerenone is the correct answer because it is a selective aldosterone antagonist without endocrine side effects. This means that it specifically targets aldosterone receptors in the body, helping to block the effects of aldosterone without interfering with other hormones. In contrast, Spironolactone (choice A) can have endocrine side effects due to its non-selective action on aldosterone receptors. Amiloride (choice B) and Triamterene (choice D) are potassium-sparing diuretics that work by blocking sodium channels in the distal tubules of the kidneys, but they do not specifically target aldosterone receptors like Eplerenone does.

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