NAPLEX (North American Pharmacist Licensure Examination) Practice Exam

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Which antidepressant does not require tapering due to its long half-life?

  1. Fluoxetine

  2. Paroxetine

  3. Citalopram

  4. Escitalopram

The correct answer is: Fluoxetine

Fluoxetine is the correct answer because it has a long half-life compared to the other options listed. Due to its long half-life, fluoxetine does not require tapering when discontinuing the medication as much as other antidepressants with shorter half-lives. In contrast, the other options such as Paroxetine, Citalopram, and Escitalopram have shorter half-lives and therefore may require tapering to prevent withdrawal symptoms when being discontinued.

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